Understanding the immune system as a complex ecosystem, in dynamic perception and cognition of molecular and cell perturbations in changing context requires systems immunology. Approaches focus on lymphocyte population dynamics, differentiation, diversity, selection of repertoires, studying the physiology of the immune system from development to aging, and the control of immune responses in health and diseases. We have developed animal models associated to multi-parameter and multi-level approaches to investigate the immune system and responses to perturbations, as well as mathematical and computer modelling to help in the interpretation of the multi-scale data. We considered the analysis of T lymphocytes phenome, repertome, cell cycle, through aging and genetic variation, for statistics and mechanical reconstruction of lymphocyte dynamics, from their generation and selection in the thymus to the control of immune responses.
Links to Publications
- Lavelle, C., H. Berry, G. Beslon, F. Ginelli, J. Giavitto, Z. Kapoula, A. Le Bivic, N. Peyrieras, O. Radulescu, A. Six, V. Thomas-Vaslin and P. Bourgine (2008). “From molecules to organisms: towards multiscale integrated models of biological systems.” Theoretical Biology Insights 1: 13-22.
- Thomas-Vaslin, V., Altes, H. K., de Boer, R. J., and Klatzmann, D. (2008). Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. J Immunol 180, 2240-2250.https://www.ncbi.nlm.nih.gov/pubmed/18250431
- McEwan, H. Bersini, D. Klatzmann, V. Thomas-Vaslin, A. Six. A computational technique to scale mathematical models towards complex heterogeneous systems (2011), COSMOS 2011 Conference Proceeding of the 2011workshop on complex systems modeling and simulation Luniver press. IBSN 978-1-905986-32-3
- Bersini, H., D. Klatzmann, A. Six and V. Thomas-Vaslin (2012). “State-Transition Diagrams for Biologists.” PloS one 7 (7), e41165. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041165
- Thomas-Vaslin, V., A. Six, H. P. Pham, C. Dansokho, W. Chaara, B. Gouritin, B. Bellier and D. Klatzmann (2011). Immunodepression & Immunosuppression in aging mice Immunosuppression. M. B. Portela. Brazil, InTech open acces publisher.
- Thomas-Vaslin, V., A. Six, B. Bellier and D. Klatzmann (2013). Lymphocyte Dynamics and Repertoires, Biological Methods. Encyclopedia of Systems Biology. W. Dubitzky, O. Wolkenhauer, K.-H. Cho and H. Yokota, Springer New York: 1145-1149 http://link.springer.com/referenceworkentry/10.1007%2F978-1-4419-9863-7_95
- Thomas-Vaslin, V., A. Six, B. Bellier and D. Klatzmann (2013). Lymphocytes dynamics repertoires, modeling. Encyclopedia of Systems Biology. W. O. Dubitzky W, Springer, Heidelberg NewYork. http://link.springer.com/referenceworkentry/10.1007/978-1-4419-9863-7_96
- Thomas-Vaslin, V., A. Six, J. G. Ganascia and H. Bersini (2013). “Dynamical and mechanistic reconstructive approaches of T lymphocyte dynamics:Using visual modelling languages to bridge the gap between immunologists, theoreticians and programmers.” Frontiers in Immunology http://www.frontiersin.org/Journal/Abstract.aspx?s=1177&name=t_cell_biology&ART_DOI=10.3389/fimmu.2013.00300
- THOMAS-VASLIN, V. (2014). “A complex immunological idiotypic network for maintenance of tolerance.” Frontiers in Immunology 5.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00369/full
- Vibert, J. and V. Thomas-Vaslin (2017). “Modelling T Cell Proliferation: Dynamics Heterogeneity, Depending on Cell Differentiation, Age, and Genetic Background.” PLos Comput Biol 13 (3): e1005417. http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.10054
- THOMAS-VASLIN, V. (2017). Understanding and modeling the complexity of the immune system. First Complex Systems Digital Campus World E-Conference 2015, Tempe, United States, Springer.https://hal.archives-ouvertes.fr/hal-01291113/document
- video: http://cs-dc-15.org/papers/organisms/cognitive-immune-sys/understanding-and-modelling-the-complexity-of-the-immune-system/